However, one of my favorites is using supervised learning techniques, such as random forest, SVM, and XGBoost, to discover which features contribute the most to the success of a product. Newsletter, Details are provided in Data S2.B. Financial support for ScienceDaily comes from advertisements and referral programs, where indicated. 1c). Nature (Nature) Individuals at this site might mark one of the last occurrences of such high levels of hunter-gatherer-related ancestries, just centuries before the emerging European Bronze Age. The admixture graph shows that the Bacho Kiro IUP group (n=3) shares ancestry with multiple early modern human lineages2 (Supplementary Information, section7), and that the more than 45,000-year-old Zlat k genome1 is the most deeply divergent non-African lineage sequenced to date (Extended Data Fig. Tina Huangis a data scientist currently working at a large FAANG enterprise. and T. Saupe received support from the European Union through the European Regional Development Fund (project no. In panel a, genetic affinity between different ancestries is indicated by thick lines or shades, while admixture is indicated with arrows. 2, 17561762 (2007). Pleistocene mitochondrial genomes suggest a single major dispersal of non-Africans and a Late Glacial Population turnover in Europe. Nat. Libraries showing a mitochondrial or nuclear contamination rate over 10% were considered substantially contaminated whereas those between 5 and 10% were considered marginally contaminated and were treated differently (details are provided in Supplementary Information, section3). Nature 513, 409413 (2014). She majored in mathematics before switching to computer science. 2a). Disease-modifying, readily available, and easily affordable medical therapies for hypertension are ubiquitous and set a high bar for any new therapeutic. I'm a data scientist and youtuber. Raghavan, M. et al. W jednej z historii misiaczki za rad pewnej wydry zamieszkuj w tajemniczym domostwie. Nature 536, 419424 (2016). We also compared its affinity to El Mirn (northern Spain), the oldest Magdalenian-associated individual sequenced to date (19ka). A high-coverage genome sequence from an archaic Denisovan individual. Ecologizr. To bind DNA, silica columns for high volumes (High Pure Viral Nucleic Acid Large Volume Kit (Roche)) were used. iScience 25, 104244 (2022). 5 Cliches About computer science flow chart You Should Avoid, What Freud Can Teach Us About brief candle in the dark my life in science. Extended Data Fig. Cuando se ampla, se proporciona una lista de opciones de bsqueda para que los resultados coincidan con la seleccin actual. C.L.S. Earlier I had practiced a bit of MySQL, but here through this course I got introduced to PostgreSQL. Edit your profile. Radiocarbon 55, 163177 (2013). However, the genetic profile of contemporaneous Gravettian-associated individuals from western Europe remains unknown, as is their contribution to populations after the LGM. The inferred pattern of short ROH (48 cM, visualized in blue) being common is in stark contrast to most later farmer populations, where the majority of individuals have no short ROH whatsoever (see101), and evidences small effective population sizes across West Eurasian hunter-gatherer groups. Data Visualization Explained: Candlestick Chart, R Programming for Statistics and Data Science 2020. Meet Tina Huang. The purified products were amplified in multiple 100l reactions using Herculase II Fusion DNA Polymerase (Agilent) following the manufacturers specifications with 0.3M of the IS5/IS6 primers. Nat. The y axis shows the average of calibrated radiocarbon dates in thousands of years (kyr) (Supplementary Data 1.A). First up is the MIT researcher and YouTuber Jordan Harrod. To gain an overview of the genomic background of European hunter-gatherers before the LGM, we used multidimensional scaling (MDS) to plot a dissimilarity matrix of pairwise outgroup f3-statistics in the form 1f3(Mbuti; pop1, pop2) (Fig. Empirically, the results show that the proposed BERT fine-tuning model with the SRS technique achieves better results. Lipson, M. et al. On top of that, its full of useful career and productivity advice, so you can find out what knowledge you need to become a data scientist as well as how to break into the field. They were different in many aspects, including their skin and eye colour," says He Yu. Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers, https://doi.org/10.1038/s41586-023-05726-0. 27 and 28 and Supplementary Data 3.G. The genetic distinction between the Oberkassel and Sidelkino clusters is also clearly noticeable in the diversity of uniparentally inherited markers, as the Oberkassel cluster is dominated by mtDNA haplogroup U5 and Y-chromosome haplogroup I, whereas individuals from the Sidelkino cluster show a higher frequency of mtDNA haplogroups U2, U4 and R1b, and carry uniquely Y-chromosome haplogroups Q, R and J (Extended Data Figs. 4, 11 (2007). Moreover, previous studies have shown that El Mirn carries a genetic contribution from the Villabruna cluster, which is found in Epigravettian-associated individuals from Italy4,15. As previously hinted37, we find a large frequency variation in alleles related to skin and eye pigmentation among post-LGM hunter-gatherer groups. To mark the occasion, rather than doing some data analysis or looking at trends, we wanted to dedicate this bulletin to seven women in tech, data, and science that you should know about. One of the best-known and most liked personalities in the data community, Tina is a successful YouTuber and works with one of the FAANG companies. In product development, we do lots of opportunity sizing to decide which features to build and what opportunities to invest in. Commun. Third, Magdalenian-associated individuals not only from Iberia but also from the rest of Europe carry Epigravettian-associated ancestry (Villabruna cluster). Biol. Using DATES software, we estimated the admixture between Villabruna/Oberkassel and ANE ancestries in these old Sidelkino-cluster-related individuals to around 1513ka (Extended Data Fig. The genomic similarity of the Oberkassel cluster to Arene Candide 16 in northwestern Italy might imply that Epigravettian-associated ancestry spread from the south to central Europe passing through the western side of the Alpine region. This might also explain the genetic uniformity of the Oberkassel cluster across large parts of western Eurasia but genomic data from between 15 and 14ka is needed to understand the exact dynamics of this turnover. Max Planck Institute for Evolutionary Anthropology. Basically, you minimize effort and maximize outcomes. Tina Llorca CPA, CWP, CEPP, CIS, MDRT Expand search. 1a, and the y-axes report time in thousand years before present (kBP). C. Posth, H.Y., A.G., A.B.R., W.H. Genome sequence of a 45,000-year-old modern human from western Siberia. These results show that some, but not all, of the genomic ancestries present in Europe between around 40ka and 30ka survived in the Gravettian-associated populations studied so far. Gonzlez-Fortes, G. et al. BMC Bioinformatics 15, 356 (2014). A recent bottleneck of Y chromosome diversity coincides with a global change in culture. 13). Definitely a course worth investing in as it sticks out as a unique course focusing on SQL interviews and doesn't contribute to the abundance of generic courses on the internet! a, Population structure among Epigravettian-associated populations revealed by a neighbour-joining tree based on pairwise f2 genetic distances. 276, 107319 (2022). Preistoria e Antropologia, Universit degli Studi di Siena, Siena, Italy, Stefano Ricci,Francesco Boschin&Annamaria Ronchitelli, Centro Studi sul Quaternario ODV, Sansepolcro, Italy, Institut National de Recherches Archologiques, Bertrange, Luxembourg, Department of Cultural Heritage, University of Bologna, Ravenna, Italy, Gregorio Oxilia,Eugenio Bortolini,Stefano Benazzi&Matteo Romandini, Human Ecology and Archaeology (HUMANE), Department of Archaeology and Anthropology, Instituci Mil i Fontanals de Investigacin en Humanidades, Consejo Superior de Investigaciones Cientficas (IMF - CSIC), Barcelona, Spain, UMR 7209Archozoologie et Archobotanique-Socits, Pratiques et Environnements, Musum National dHistoire Naturelle, Paris, France, Dipartimento di Scienze Della Vita e DellAmbiente, Sezione di Neuroscienze e Antropologia, Universit Degli Studi di Cagliari, Cittadella Monserrato, Cagliari, Italy, Dipartimento di Civilt e Forme Del Sapere, Universit di Pisa, Pisa, Italy, Center for Isotope Research, Groningen University, Groningen, The Netherlands, UMR 7206 co-Anthropologie, quipe ABBA. Everything you need to know is included in the course. In the MDS plot, we find that all of the newly and previously reported Epigravettian-associated individuals fall within the Villabruna cluster4 (Fig. In it, we laugh while discussing how to get started in data science and her learning/productivity tricks.Tina: Creates YouTube videos with millions of views on data science careers, learning to code, SQL, productivity, and study techniques. Is a data scientist at one of the world's largest tech companies (she keeps the firm anonymous so she can publish more freely). Previously worked at Goldman Sachs and the Ontario Institute for Cancer Research. Holds a Masters in Computer and Information Technology from the University of Pennsylvania and a bachelors in Pharmacology from the University of TorontoIn this episode, Tina details: Her guidance for preparing for a career in data science from scratch. Her five steps for consistently doing anything. Her strategies for learning effectively and efficiently. What the day-to-day is like for a data scientist at one of the worlds largest tech companies. The software languages she uses regularly. Her SQL course. How her science and computer science backgrounds help her as a data scientist today.Todays episode should be appealing to a broad audience, whether youre thinking of getting started in data science, are already an experienced data scientist, or youre more generally keen to pick up career and productivity tips from a light-hearted conversation.Thanks to Serg Mass, Brindha Ganesan and Ken Jee for providing questions for Tina in Ken's case, a very silly question indeed.The SuperDataScience show's available on all major podcasting platforms, YouTube, and at SuperDataScience.com. eLife 11, e77625 (2022). Admixture graphs were reconstructed using qpGraph 6450, with allsnps mode to correct for low-coverage sample and Mbuti.DG set as the outgroup. Mol. Your email address will not be published. Tina Huang is a statistician who focuses on the statistical modeling and analysis of big data. Bioinformatics 29, 16821684 (2013). Google Scholar. Reimer, P. J. et al. Similarly, the SMS spam collection data achieves 99.20% for the validation and 99.10% for testing. Write a sharp and effective resume in minutes and get noticed by employers. "With these findings, we can for the first time directly support the hypothesis that during the Last Glacial Maximum people found refuge in the climatically more favourable region of southwestern Europe" says first author Cosimo Posth. Teaching Assistant. What is Marimekko Chart in Data Visualization? In the meantime, to ensure continued support, we are displaying the site without styles 2022 Weird Science Plus - All Rights Reserved. What is a Scatterplot in Data Visualization, Machine Learning in R: Building a Classification Model. received support from the Estonian Research Council grant PUT (PRG243). Citations 52. PubMed Central Designed for aspiring data scientists, data analysts, and BI analysts, this course is the perfect resource for anyone who needs a winning strategy to pass the SQL interview and land their dream job. For phylogenetic reconstruction (Extended Data Fig. . PACEA co-authors of this research benefited from the scientific framework of the University of Bordeauxs IdEx Investments for the Future programme/GPR Human Past. Schubert, M., Lindgreen, S. & Orlando, L. AdapterRemoval v2: rapid adapter trimming, identification, and read merging. Wonderful course so far Tina. This research aims to determine whether a neural response telemetry (NRT) threshold determines the success of surgery. The White House and federal agencies in the U.S. declare the Year of Open Science, listing several actions towards open science. Hi! Tina Huang Data Scientist. Ice Age survivors. Otte, M. Appearance, expansion and dilution of the Magdalenian civilization. Int. Huang, Y. This website is about taking one step at a time to ultimately live more fulfilling lives. Sci. Individuals and groups are plotted with the same colours and symbols as in Fig. Finally, unsupervised clustering and more complex techniques, such as deep learning, also have their place. Tina Huang Fans Also Viewed . With the statistics f4(Mbuti, Fournol 85; Vstonice, test) and f4(Mbuti, Vstonice; Fournol 85, test), we show that all Vstonice-cluster individuals are significantly closer (|Z|>3) to the Vstonice group (n=5) and the Fournol-cluster individuals are closer to Fournol 85, whereas the geographically intermediate Gravettian-associated Goyet group shows extra affinity to both clusters (Fig. After a period of limited admixture that spanned the beginning of the Mesolithic, we find genetic interactions between western and eastern European hunter-gatherers,who were also characterized by marked differences in phenotypically relevant variants. First Name Tina #39. Become an in-demand #DataScience professional TODAY with the 365 Data Science Program -> https://365datascience.com, analyzing similar products to compare how they performed, data visualizations with SQL and Python or R. During this time agriculture and a sedentary lifestyle spread from Anatolia to Europe. & Dolukhanov, P.) 122145 (Avebury, 1993). Negative and positive controls were carried alongside each experiment. It involves lots of hypothesis testing and statistics which 365 Data Science also has a wonderful course on. 5 and Extended Data Fig. Also if you want to see some cat pics. Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans. Curr. Soonafter8 ka, Sidelkino ancestry was absent in eastern Spain but it had already reached northern Iberia alongside an increase in Oberkassel ancestry (Fig. In no time, she established herself as one of the favorite vloggers of the data community. PubMed Consultant - October 2015 to June 2016. Los Angeles, California, United States. T.T., D.C. and E.A. Can you tell I had fun filming this episode with Tina Huang, YouTube data science superstar (293k subscribers)? Nat. The MySQL engine is also known for being extremely slow compared to others. 10, 552010 (2019). I am attending the Future of Data and AI by Data Science Dojo on March 1st and 2nd, 2023. Sci. It just raised $12.2 million. Therefore, contrary to previous suggestions34, this demonstrates that the post-LGM diffusion of the Magdalenian was indeed associated with northward and northeastward population expansions from western Europe35. Nature 582, 384388 (2020). My name is Tina and I'm a data scientist and YouTuber. Mathieson, I. et al. Modern humans have populated Europe for more than 45,000 years 1, 2. She is concise, pragmatic and to the point in the videos and it is easy to follow her lectures. After the LGM, the Epigravettian culture was widespread in southern andsoutheastern Europe. Svensson, E. et al. My name is Tina and I'm a data scientist at a FAANG company. This is further validated by f4-statistics of the form f4(Mbuti, Arene Candide 16; Goyet Q-2, Magdalenian-associated individuals), which is significantly positive only for El Mirn, whereas all other tested individuals and Goyet Q-2 are symmetrically related with respect to Arene Candide 16 (Supplementary Fig. The data generated in this study enabled us to investigate genomic transformations of and interactions between Eurasian hunter-gatherers at high resolution (Extended Data Fig. 16, e2003703 (2018). Develped strategies for promoting G-Mark to Taiwan. 44, W58W63 (2016). If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Meyer, M. et al. I'm interested in tech, trading, and how to minimize effort and maximize outcome. Le palolithique suprieur en Italie. A. Stoessel performed CT scanning and advised on sampling strategy. Sci. Individuals in western and southwestern Europe related to the Fournol cluster are consistently deposited in cave sites and occasionally exhibit anthropogenic marks whereas individuals related to the Vstonice cluster are buried with grave goods and/or personal ornaments and ochre in open air or cave sites in central-eastern and southern Europe, respectively (Supplementary Figs. "It is possible that the migration of early farmers into Europe triggered the retreat of hunter-gatherer populations to the northern edge of Europe. H. Rougier and I.C. The latter was created as a support network for women in the industry to discuss, share, and learn from each other.. Mateja Hajdinjak, Fabrizio Mafessoni, Svante Pbo, D. M. Fernandes, D. Strapagiel, R. Pinhasi, Pavel Flegontov, N. Ezgi Altnk, Stephan Schiffels, Daniel M. Fernandes, Kendra A. Sirak, David Reich, Sandra Oliveira, Kathrin Ngele, Mark Stoneking, Eirini Skourtanioti, Harald Ringbauer, Philipp W. Stockhammer, Vanessa Villalba-Mouco, Marieke S. van de Loosdrecht, Wolfgang Haak, Joseph H. Marcus, Cosimo Posth, John Novembre, Natalija Kashuba, Emrah Krdk, Anders Gtherstrm, Nature Lead Advisor - Data Science. The formation of human populations in South and Central Asia. Natl Acad. The key areas to focus on when getting started in data science [6:01] Tina's five steps to consistently doing anything [11:55] Tina's day-to-day life as a data scientist at one of the world's largest tech companies [20:02] How Tina's computer science background helps her work [26:20] Traditional banking culture vs big tech [32:12] Biol. The mitochondrial capture sequencing reads were cleaned by AdapterRemoval 2.2.0 to remove the adapters and reads with lengths below 30bp. The Kostenki (and Sunghir group) ancestry contributed to the previously described Vstonice cluster represented by Gravettian-associated individuals from central-eastern and southern Europe4. On the basis of f4-statistics, we find that individuals assigned to the Oberkassel cluster are closer to the Arene Candide 16 genome than any other Epigravettian-associated group from Italy (Supplementary Data 2.F). Bortolini, E. et al. The authors thank G. Marciani and O. Jris for comments on archaeology; C. Jeong, M. Spyrou and K. Prfer for comments on genetics; M. OReilly for graphical support for Fig. The pathway program not only helps students to strengthen their English, but more importantly, it helps students to understand and adapt to the expections of university.". The horizontal dashed line marks the boundary between Late Pleistocene and Holocene. This affinity is even stronger towards Epigravettian-associated individuals from western and central Italy and Sicily (group 2 and group 3, respectively) than to those from northern Italy (group 1) (Supplementary Data 2.F). 4, 324333 (2020). B. et al. We looked at data on how many people had been dropped, the time when they were dropped, and the time they were found. The inferred topology reveals a phylogeographic pattern irrespective of individual ages. Youll be surprised how much value there is in a quick XGBoost model, for example. 5). You can also check out our video on the topic below or scroll down to keep on reading. The end goal is to create and grow a product that users love. Klaric, L., Goutas, N., Laccarire, J. Write for us- Weird Science, Energy & Minerals Guest Post. Dr. Huang taught General Chemistry, Quantitative Analysis, and Instrumental Methods for eight years at . To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. To obtain Every Thursday, I share insights from books, learning & productivity tips, and a coding challenge. However, the extent to which groups associated with the Solutrean culture are in genetic continuity with earlier and later populations from the same region is unknown because no genomic data from Solutrean-associated individuals have been reported previously. What is surprising is that the Code Cup was so popular that Stanford decided to throw open a Data Science Week in which anyone can submit a code challenge to the top 200 submissions. We then removed samples with less than 0.04X coverage (calculated on the mappable, non-recombining region of the Y chromosome98) to avoid arbitrarily placing low-coverage samples at the root of major haplogroups. The more information you have the more data you need to analyze and make your predictions. Test cases development, automated test tool design, and validation testing for Alaris' first attachable/detachable infusion pump, which is . Paradis, E., Claude, J. I hold a Bachelors degree at the University of Toronto where I studied pharmacology.
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